Effect of acute and chronic coenzyme Q10 supplementation on creatine kinase after exhaustive aerobic activity

Document Type : Original Article

Authors

Department of Physiology, Razi University, Kermanshah, Iran

Abstract

Introduction: Fatigue and muscle ache, is a common and prevalent experience after physical activity, especially exhausting activities. The purpose of this study was to investigate the acute and chronic effects of supplementation of coenzyme Q10 on creatine kinase after exhausting aerobic activity in soccer players. 
Methods: Twelve male soccer players who did not have a history of muscular injury since six months ago volunteered to participate in the study. They were examined in three groups of acute, chronic and control. In order to induce muscle damage, a Bruce exhaustive test was performed and to determine the level of creatine kinase blood samples were taken before and after Bruce test. In the acute situation, one day before the Bruce test, two Q10 supplements (each 100 mg) and in chronic situation Bruce''s test was performed after eight weeks of supplementation. To analyze the data, dependent t-test was used at a significant level of P ≤ 0.05.
Results: Diagnosis of muscle damage was assessed by measuring the biochemical changes of the creatine kinase enzyme. Statistical analysis showed no significant changes in the level of creatine kinase in acute situation (p>0.05), but there was a significant decrease in chronic supplementation (p

Graphical Abstract

Effect of acute and chronic coenzyme Q10 supplementation on creatine kinase after exhaustive aerobic activity

Keywords


1. Ehrman JK. American College of Sports Medicine. ACSM''sresource manual for Guidelines for exercise testing and prescription. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2010; pp 2-84.
2. Fu X, Ji R, and Dam J. Antifatigue effect of coenzyme Q10 in mice. J Med Food. 2010;13:211-5.
3. Shimomura Y, Suzuki M, Sugiyama S, Hanaki Y, and Ozawa T. Protective effect of coenzyme Q10 on exercise-induced muscular injury. Biochem Biophys Res Commun. 1991;176:349-55.
4. Kon M, Kimura F, Akimoto T, Tanabe K, Murase Y, Ikemune S, Kono I. Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exerc Immunol Rev. 2007;13:76-88.
5. Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K. Reducing exercise- induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr. 2008;100,903-909. doi:10.1017/S0007114508926544
6.Nejatmand N, Ramezani A, Barati A. Effect of Consumption short-term CoQ10 supplementation on markers of delayed onset muscle soreness. RJMS. 2014;21(119) ,77-85.
7. Behpoor N, Rahimi N. Study and comparison of Ultrasound and Ice massage effect on delayed onset muscle soreness (DOMS) signs. J Sport. Pec. 2010; 8:15-26.
8.Meir M, Dumke CL and Urbiztondo ZU. Relationship between serum creatine kinase activity following exercise– induced muscle damage and muscle fibrecompositin. J Sports Sci. 2010;28(3):257-66. doi:10.1080/02640410903440892
9. Zuliani U, Bonetti A, Campana M, Cerioli G, Solito F, Novarini A. The influence of ubiquinone (CoQ10) on the metabolic response to work. J Spo Med Phys Fit. 1989;29(1):57-62.
10. William JV, Stogsdill WW, Judy DS. Coenzyme Q10 facts or fabrications. Natural Products INSIDER. 2007; 2: 1 – 4.
11. Armanfar M, Jafari A, Dehghan Gh.R, Abdizadeh L. Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners. Med J Islam Repub Iran. 2015;29:202.
12. changizi M. Ebrahimi M. Avandi M. Acute effects of coenzyme Q10 supplement on serum parameters of oxidative stress following one session of resistance training in male college athlete. J Koomesh. 2015(4):603-610.
13. Andersson H, Bøhn SK, Raastad T, Paulsen G, Blomhoff R,Kadi F. Differences in the inflammatory plasma cytokine response following two elite female soccer games separated by a 72-h recovery. Scand J Med Sci Sports. 2010;20(5):740-7. doi: 10.1111/j.1600-0838.2009.00989.x  
14. Aslan R,sekeroglu.M.R,Tarakcioglu M,Bayiroglu F,Meral I. Effect of acute regular exercise on antioxidative enzymes,tissue damage markers and membrane lipid per oxidation of erytrocytes in sedentary students. Tr J  Med Sci. 1996;28,411-414.
15. Beal MF. Neurochemistry and toxin models in Huntington’s disease. Curr Opin Neurol.1994;7(6):542–547.
16. Belardinelli R, Muçaj A, Lacalaprice F. Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J. 1985;27(22):2675-2681. doi: 10.1093/eurheartj/ehl158
17.Bhaskar PA, Raut SE, Hawaldar VB. The effect ofexercise on platelet aggregagability and other cardiovascular parameters. Inte J of Basic Med Sci. 2012; 6(2):27-41
18. Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008.  5:8. doi: 10.1186/1550-2783-5-8
19. Littarru GP,Tiano L.Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.  Mol Biotechnol. 2007; 37:31-7. doi:10.1007/S12033-007-0052y